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1

Enantioselective Total Synthesis of (-)-Chlorothricolide

Roush, William R., Sciotti, Richard J.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 209 KB

english, 1994

2

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis

Van Bocxlaer, Katrien, Caridha, Diana, Black, Chad, Vesely, Brian, Leed, Susan, Sciotti, Richard J., Wijnant, Gert-Jan, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles E., Ioset, Jean-Robert,

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2019

Language:

english

File:

PDF, 739 KB

english, 2019

3

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, G

Journal:

Malaria Journal

Year:

2014

Language:

english

File:

PDF, 501 KB

english, 2014

4

Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

Caridha, Diana, Vesely, Brian, van Bocxlaer, Katrien, Arana, Byron, Mowbray, Charlie, Rifati, Sima, Uliana, Silvia, Regura, Rosa, Kreishman-Deitrick, Mara, Sciotti, Richard, Buffet, Pierre, Croft, Sim

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2019

Language:

english

File:

PDF, 765 KB

english, 2019

5

ChemInform Abstract: Synthesis of N-Arylated Oxazolidinones via a Palladium-Catalyzed Cross-Coupling Reaction. Application to the Synthesis of the Antibacterial Agent Dup-721.

David J. Madar, Hana Kopecka, Daisy Pireh, Jonathan Pease, Marina Pliushchev, Richard J. Sciotti, Paul E. Wiedeman, Stevan W. Djuric

Journal:

Year:

2001

File:

PDF, 34 KB

2001

6

ChemInform Abstract: The Synthesis and Biological Evaluation of a Novel Series of Antimicrobials of the Oxazolidinone Class.

Richard J. Sciotti, Stevan W. Djuric, et al. et al.

Journal:

Year:

2002

File:

PDF, 26 KB

2002

7

5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Jeremy T. Starr, Richard J. Sciotti, Debra L. Hanna, Michael D. Huband, Lisa M. Mullins, Hongliang Cai, Jeffrey W. Gage, Mandy Lockard, Mark R. Rauckhorst, Robert M. Owen, Manjinder S. Lall, Mark Tomi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 302 KB

english, 2009

8

Enantioselective synthesis of the top half of chlorothricolide

William R. Roush, Richard J. Sciotti

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 291 KB

english, 1992

9

Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

David J Madar, Hana Kopecka, Daisy Pireh, Jonathan Pease, Marina Pliushchev, Richard J Sciotti, Paul E Wiedeman, Stevan W Djuric

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 66 KB

english, 2001

10

Solid phase synthesis of ureas of secondary amines via carbamoyl chloride

Gary T. Wang, Yuanwei Chen, Sheldon Wang, Richard Sciotti, Thomas Sowin

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 174 KB

english, 1997

11

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

Richard J. Sciotti, Marina Pliushchev, Paul E. Wiedeman, Darlene Balli, Robert Flamm, Angela M. Nilius, Kennan Marsh, DeAnne Stolarik, Robert Jolly, Roger Ulrich, Stevan W. Djuric∗

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 96 KB

english, 2002

12

A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus

Opsenica, Igor, Burnett, James C., Gussio, Rick, Opsenica, Dejan, Todorović, Nina, Lanteri, Charlotte A., Sciotti, Richard J., Gettayacamin, Montip, Basilico, Nicoletta, Taramelli, Donatella

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

13

3,5-Bis(trifluoromethyl)pyrazoles: A Novel Class of NFAT Transcription Factor Regulator

Djuric, Stevan W., BaMaung, Nwe Y., Basha, Anwer, Liu, Huaqing, Luly, Jay R., Madar, David J., Sciotti, Richard J., Tu, Noah P., Wagenaar, Frank L., Wiedeman, Paul E., Zhou, Xun, Ballaron, Stephen, Ba

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 138 KB

english, 2000

14

Enantioselective Total Synthesis of (−)-Chlorothricolide via the Tandem Inter- and Intramolecular Diels−Alder Reaction of a Hexaenoate Intermediate

Roush, William R., Sciotti, Richard J.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 475 KB

english, 1998

15

4-Amino-7-chloroquinolines: Probing Ligand Efficiency Provides Botulinum Neurotoxin Serotype A Light Chain Inhibitors with Significant Antiprotozoal Activity

Opsenica, Igor M., Tot, Mikloš, Gomba, Laura, Nuss, Jonathan E., Sciotti, Richard J., Bavari, Sina, Burnett, James C., Šolaja, Bogdan A.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 578 KB

english, 2013

16

3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum

Das, Umashankar, Singh, Ravi S.P., Alcorn, Jane, Hickman, Mark R., Sciotti, Richard J., Leed, Susan E., Lee, Patricia J., Roncal, Norma, Dimmock, Jonathan R.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 806 KB

english, 2013

17

Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity

Sharlow, Elizabeth R., Leimgruber, Stephanie, Murray, Samantha, Lira, Ana, Sciotti, Richard J., Hickman, Mark, Hudson, Thomas, Leed, Susan, Caridha, Diana, Barrios, Amy M., Close, David, Grögl, Max, L

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

18

Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

Patel, Gautam, Roncal, Norma E., Lee, Patricia J., Leed, Susan E., Erath, Jessey, Rodriguez, Ana, Sciotti, Richard J., Pollastri, Michael P.

Journal:

Year:

2014

Language:

english

File:

PDF, 259 KB

english, 2014

19

Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria

Videnović, Milica, Opsenica, Dejan M., Burnett, James C., Gomba, Laura, Nuss, Jonathan E., Selaković, Života, Konstantinović, Jelena, Krstić, Maja, Šegan, Sandra, Zlatović, Mario, Sciotti, Richard J.,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 821 KB

english, 2014

20

Studies on the Synthesis of Chlorothricolide: Diastereo- and Enantioselective Syntheses of Model Top-Half Spirotetronate Units

Roush, William R., Sciotti, Richard J.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 167 KB

english, 1998

21

Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria

Woodring, Jennifer L., Patel, Gautam, Erath, Jessey, Behera, Ranjan, Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.

Journal:

Year:

2015

Language:

english

File:

PDF, 431 KB

english, 2015

22

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

Helgren, Travis R., Sciotti, Richard J., Lee, Patricia, Duffy, Sandra, Avery, Vicky M., Igbinoba, Osayawemwen, Akoto, Matthew, Hagen, Timothy J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 536 KB

english, 2015

23

Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice

Opsenica, Igor M., Verbić, Tatjana Ž., Tot, Mikloš, Sciotti, Richard J., Pybus, Brandon S., Djurković-Djaković, Olgica, Slavić, Ksenija, Šolaja, Bogdan A.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 750 KB

english, 2015

24

Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

Vuong, Chau, Xie, Lisa H., Potter, Brittney M. J., Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Wa

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

25

Structure-Activity Relationship (SAR): Effort Towards Blocking NGlucuronidation of Indazoles (PF-03376056) By Human UGT1A Enzymes

Rose, Kelly, Yang, Young-Sun, Sciotti, Richard, Cai, Hongliang

Journal:

Drug Metabolism Letters

Year:

2009

Language:

english

File:

PDF, 116 KB

english, 2009

26

Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis

Caridha, Diana, Parriot, Sandi, Hudson, Thomas H., Lang, Thierry, Ngundam, Franklyn, Leed, Susan, Sena, Jenell, Harris, Michael, O'Neil, Michael, Sciotti, Richard, Read, Lisa, Lecoeur, Herve, Hickman,

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 1.84 MB

english, 2017

27

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites

Devine, William, Thomas, Sarah M., Erath, Jessey, Bachovchin, Kelly A., Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 469 KB

english, 2017

28

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation

Woodring, Jennifer L., Bachovchin, Kelly A., Brady, Kimberly G., Gallerstein, Mitchell F., Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Pollas

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 719 KB

english, 2017

29

Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation

Mehta, Naimee, Ferrins, Lori, Leed, Susan E., Sciotti, Richard J., Pollastri, Michael P.

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 587 KB

english, 2018

30

Corrigendum to “Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation” [Eur. J. Med. Chem. 141 (2017) 446–459]

Woodring, Jennifer L., Bachovchin, Kelly A., Brady, Kimberly G., Gallerstein, Mitchell F., Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Pollas

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 172 KB

english, 2018

31

Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners

Konstantinović, Jelena, Videnović, Milica, Srbljanović, Jelena, Djurković-Djaković, Olgica, Bogojević, Katarina, Sciotti, Richard, Šolaja, Bogdan

Journal:

Year:

2017

Language:

english

File:

PDF, 6.69 MB

english, 2017

32

Anilinoquinoline based inhibitors of trypanosomatid proliferation

Ferrins, Lori, Sharma, Amrita, Thomas, Sarah M., Mehta, Naimee, Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Gillingwater, Kirsten, Pollastri,

Journal:

PLoS Neglected Tropical Diseases

Year:

2018

Language:

english

File:

PDF, 2.84 MB

english, 2018

33

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis

Van Bocxlaer, Katrien, Caridha, Diana, Black, Chad, Vesely, Brian, Leed, Susan, Sciotti, Richard J., Wijnant, Gert-Jan, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles E., Ioset, Jean-Robert,

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2019

File:

PDF, 739 KB

2019

34

Structure–Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni

Buskes, Melissa J., Clements, Monica, Bachovchin, Kelly A., Jalani, Hitesh B., Leonard, Allison, Bag, Seema, Klug, Dana M., Singh, Baljinder, Campbell, Robert F., Sciotti, Richard J., El-Sakkary, Nell

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.49 MB

2020

35

Safety, pharmacokinetics, and activity of high-dose ivermectin and chloroquine against the liver-stage of Plasmodium cynomolgi infection in Rhesus Macaques

Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J., Reichard, Gregory

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 776 KB

2020

36

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

Nagle, Advait, Biggart, Agnes, Be, CÃ©line, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon S, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin, Gao, Mu-Yun,

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.28 MB

2020